{"product_id":"l-carnosin-im-glas","title":"L-carnosine","description":"\u003ch6\u003e\u003cspan\u003eHIGHLIGHTS\u003c\/span\u003e\u003c\/h6\u003e\n\u003cdiv class=\"mill-article-advantages has--border is--rounded\"\u003e\n\u003cul class=\"mill-article-advantages--list list--unordered\"\u003e\n\u003cli\u003e\n\u003cspan\u003e\u003cstrong\u003eBODY-IDENTIAL SHAPE\u003c\/strong\u003e - L-Carnosine is formed from the amino acids alanine and histedine. \u003c\/span\u003e\u003cspan\u003eIt is mainly found in meat and animal products, so vegans, vegetarians and older people often have a carnosine deficiency.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli class=\"a-spacing-mini\"\u003e\u003cspan class=\"a-list-item\"\u003e\u003cstrong\u003e100% VEGAN \u003c\/strong\u003e- Purely plant-based amino acid L-carnosine from the fermentation of non-GMO corn. The microorganisms used for fermentation are fed exclusively with purely plant-based raw materials. No animal components such as gelatin, hair, or feathers are used in production; only plant-based, renewable raw materials are employed.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"a-spacing-mini\"\u003e\u003cspan class=\"a-list-item\"\u003e\u003cstrong\u003eGLASS INSTEAD OF PLASTIC \u003c\/strong\u003e- We do not use plastic packaging, but fill our L-carnosine capsules into light-protected amber glass bottles, which are sealed with an aluminum lid.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"a-spacing-mini\"\u003e\u003cspan class=\"a-list-item\"\u003e\u003cstrong\u003eMADE IN GERMANY\u003c\/strong\u003e – Our high-dose L-carnosine capsules are carefully manufactured in certified facilities here in Northern Germany.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"a-spacing-mini\"\u003e\u003cspan class=\"a-list-item\"\u003e\u003cstrong\u003eLABORATORY TESTED\u003c\/strong\u003e - Each batch is laboratory tested, u.a.  for heavy metals, microbial contamination and pesticides \u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"a-spacing-mini\"\u003e\u003cspan class=\"a-list-item\"\u003e\u003cstrong\u003eTRUE CLEAN LABEL\u003c\/strong\u003e - No fillers or additives. No magnesium stearate. It contains only what is declared on the product label.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"a-spacing-mini\"\u003e\u003cspan class=\"a-list-item\"\u003e\u003cstrong\u003eGRAINY STRUCTURE\u003c\/strong\u003e - L-Carnosine is chemically a dipeptide (made up of beta-alanine and histidine). Such substances naturally have a rather \u003cem\u003e\u003cstrong\u003ecrystalline\u003c\/strong\u003e\u003c\/em\u003e Structure. If the raw material is not \u0026quot;buffered\u0026quot; with additives or if no flow agents or anti-caking agents are used, it remains \u0026quot;granular.\u0026quot; This is not a quality defect, but rather an indication of our \u0026quot;clean label\u0026quot; philosophy.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch6\u003e\n\u003cbr\u003e\u003cbr\u003eWHAT EXACTLY IS L-CARNOSINE?\u003c\/h6\u003e\n\u003cp\u003eCarnosine is produced in the body itself from histidine and alanine, and is also found in animal-based foods. Therefore, vegetarians and vegans are often deficient in L-carnosine. Furthermore, our L-carnosine levels decline with age, decreasing by approximately 63% between the ages of 10 and 70. \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCarnosine is found primarily in long-lived cells, such as muscles, the brain, but also the kidneys and liver. Carnosine is also frequently referred to as a neuropeptide.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch6\u003eEXCURSUS AGES\u003c\/h6\u003e\n\u003cp\u003eGlycation refers to the irreversible reaction of proteins and lipids with carbohydrates (v.a.  The sugars fructose, galactose, and glucose). Glycated reaction products are called \u0026quot;Advanced Glycation Endproducts\u0026quot; (AGEs).\u003c\/p\u003e\n\u003cp\u003eFoods that raise blood sugar the most also exhibit the highest AGE formation. For example, fructose is a stronger AGE-forming agent than glucose. Grains are another example. v.a.  Wheat is known to be a strong AGE former.\u003c\/p\u003e\n\u003cp\u003eFurthermore, AGE formation is promoted by oxidative stress and chronic inflammation.\u003c\/p\u003e\n\u003cp\u003eAGEs can not only be produced endogenously in the body, but can also be ingested through food. The AGE content of foods varies considerably. Meat, sausage, ham, and cheese contain high levels of AGEs. Grilling, roasting, frying, and prolonged cooking can increase the AGE content many times over. Generally, foods containing a lot of saturated fatty acids are higher in AGEs.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eWhy are AGEs harmful?\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eAGEs are involved in the development of various chronic inflammatory diseases, e.g.Type II diabetes mellitus, vascular and cardiovascular diseases, osteoporosis and arthritis.\u003c\/p\u003e\n\u003cp\u003eThe underlying cause is thought to be that glycation disrupts the functionality of important regulatory enzymes and membrane systems, while AGEs themselves also influence important metabolic processes:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBy binding to the AGE receptor (RAGE) on inflammatory cells, they induce NFkB and thus systemic inflammation and oxidative stress.\u003c\/li\u003e\n\u003cli\u003eThis stimulates the release of interleukin-1, interleukin-6, TNF-α and insulin-like growth factor-1 (IGF-1) in monocytes and macrophages.\u003c\/li\u003e\n\u003cli\u003eEndothelial cells express adhesion molecules such as VCAM-1 and ICAM-1, leading to endothelial inflammation.\u003c\/li\u003e\n\u003cli\u003eAGEs can also activate inducible NO synthase (iNOS) and thereby promote nitrosative stress.\u003c\/li\u003e\n\u003cli\u003eAll the mediators mentioned enhance u.a.  Insulin resistance.\u003c\/li\u003e\n\u003cli\u003eFurthermore, the activation of NFkB increases the cell expression of RAGE, which further enhances the pro-inflammatory effect of AGEs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSources: \u003c\/p\u003e\n\u003cp\u003e[1] Sakai M, Experimental studies on the role of fructose in the development of diabetic complications. Kobe J Med Sci. 2002; 48:125-36.\u003c\/p\u003e\n\u003cp\u003e[2] Schiekofer S. et al.: Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42\/44 MAPK, and nuclear factor kappaB in PBMCs. Diabetes 52, 2003, pp. 621–633\u003c\/p\u003e\n\u003cp\u003e[3] Koschinsky T, et. al. An environmental risk factor in diabetic nephropathy. PNAS 94, 1997, pp. 6474-6479\u003c\/p\u003e\n\u003cp\u003e[4] Sanguineti R. et al.: Advanced Glycation End Products Play Adverse Proinflammatory Activities in Osteoporosis. Mediators of inflammation 2014, 2014, p. 975872\u003c\/p\u003e\n\u003cp\u003e[5] Vlassara H et al. Recent progress in advanced glycation and diabetic vascular disease: role of advanced glycation end product receptors. Diabetes 1996; 45:65-66\u003c\/p\u003e\n\u003cp\u003e[6] Chuah et al.: Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases. Int J Inflammation 2013, 2013, p. 403460\u003c\/p\u003e\n\u003cp\u003e[7] Ott C. et al. Role of advanced glycation end products in cellular signaling. Redox biology 2, 2014, pp. 411–429\u003c\/p\u003e\n\u003cp\u003e[8] Wewer RM Arteriosclerosis and the two faces of endothelial nitric oxide synthetase Circulation 1998; 97: 108-112\u003c\/p\u003e\n\u003cp\u003e[9] Singh VP et al.: Advanced Glycation End Products and Diabetic Complications. Korean Journal of Physiology \u0026amp; Pharmacology 18, 2014, pp. 1–14\u003c\/p\u003e\n\u003cp\u003e[10] Angeloni C. Role of Methylglyoxal in Alzheimer's Disease. BioMed Res Int 2014 p. 238485\u003c\/p\u003e\n\u003cp\u003e[11] Uribarri J et al. Single oral challenge by advanced glycation end products acutely impairs endothelial function in diabetic and nondiabetic subjects. Diabetes care.2007;30:2579-82\u003c\/p\u003e\n\u003cul\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003ch6\u003eTHE MOST IMPORTANT THINGS AT A GLANCE\u003c\/h6\u003e\n\u003cdiv class=\"dhh_hinweis_detail\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"dhh_hinweis_detail\"\u003e\n\u003cdiv class=\"html--title panel--title is--underline\"\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cbr\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eContents (grams per sales unit)\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e74.4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eContents (capsules or ml per sales unit)\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e120\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eIngredients\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e\u003cspan class=\"fontstyle0\"\u003eL-Carnosine, coating agent\u003cbr\u003e(Hydroxypropylmethylcellulose)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eActive ingredients\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003eL-Carnosine\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eDosage (mg\/capsule)\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e500\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eDaily intake (capsules or drops)\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eDosage form\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e\u003cspan\u003eHard capsule\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eVegan\/vegetarian\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e\u003cspan\u003eVegan\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003ecertified organic\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003eNo\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eMade in (country)\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e\u003cspan\u003eGermany\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eStorage per package (days)\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e120\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003ePackaging (glass\/pouch bag)\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e\u003cspan\u003eGlass\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003ecategory\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003eAmino acids\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eEAN\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e4260705871527\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 45.8971%;\"\u003e\u003cspan\u003eSKU\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2117%;\"\u003e\u003cspan\u003eQI0101\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"html--title panel--title is--underline\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003ch6 class=\"html--title panel--title is--underline\"\u003e\n\u003cspan\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cdiv class=\"html--title panel--title is--underline\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"QIDOSHA GmbH","offers":[{"title":"Default Title","offer_id":45039429878027,"sku":"9P-LILC-042K","price":25.16,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0588\/7577\/3098\/files\/Qidosha_L-Carnosin_Bild_nr1.jpg?v=1724852652","url":"https:\/\/qidosha.com\/en-at\/products\/l-carnosine-in-a-glass","provider":"QIDOSHA","version":"1.0","type":"link"}