Melatonin mouth spray liposomal 30ml (Attention: sale not permitted in Switzerland)

• Premium mouth spray to shorten the time it takes to fall asleep
• Significantly higher bioavailability and thus faster and better effectiveness thanks to QIDOSHA Bio+ Technology - a purely natural, lipid-based transport system for active ingredients such as melatonin
• The significantly higher bioavailability results from two effects:
• Firstly, the advantages of liposomal dietary supplements, where the active ingredient enclosed by a phospholipid bimembrane This allows it to be absorbed much better by the cells.
• Secondly, from a Particle size of the active ingredient of <100 nm, which can significantly increase bioavailability compared to conventional liposomal products (s.u. ).
• Practical application as an aromatic, soothing mouth spray with Orange flavor made from natural orange peel oil
• Easy absorption of the active ingredients via the oral mucosa for optimal bioavailability.
• Fewer side effects due to a reduced need for active components resulting from significantly higher bioavailability
• Production and bottling take place exclusively in Germany.
  
• All ingredients are 100% vegan, GMO-free, and developed without animal testing.

Ingredients per daily serving

• Melatonin: 0.5 mg per spray

Application

Spray once into your mouth and hold for 1 minute (then swallow). Shake the spray briefly before use.

Melatonin …

• contributes to alleviating the subjective feeling of jet lag
• helps to shorten the time it takes to fall asleep.

The human body consists of 65–70% water. Therefore, fat-soluble substances like melatonin or plant extracts are poorly absorbed. Often, only 5–10% of orally ingested active ingredients are actually absorbed by the body. The patented technology behind the QIDOSHA Bio+ These products encapsulate these fat-soluble substances in a water-soluble shell (an "oil-in-water emulsion"). The phospholipid membrane in which the active ingredients are encapsulated is very similar to the structure of human cells and therefore optimizes absorption, as the body recognizes the phospholipids as its own substance.

In addition, the one behind the QIDOSHA Bio+ The technology used in these products – unlike micellar formulations – features a large oil phase of 8-15 m%. This results in a high loading capacity for the melatonin.

This unique process allows the valuable active ingredients to reach their full potential.

Our QIDOSHA Bio+ This product series is specifically designed for the optimal absorption of fat-soluble active ingredients such as melatonin: Thanks to the small particle size of the carrier molecules, QIDOSHA Bio+ Depending on the product, it offers up to 15x increased bioavailability compared to ordinary dietary supplements.

The The reduction in size of the active ingredient droplets is achieved through high-pressure homogenization. on particle sizes of less than 100 nm. This is necessary because oil/fat-soluble substances and water do not usually mix, but rather form separate phases. Even if they do form, emulsions and liposomes tend to aggregate; d.h. They form increasingly larger particles until they reach a point where they are no longer compatible with water.

The negative correlation between bioavailability and particle size is in u.g. A graphic is presented that illustrates the results of relevant studies. This effect is particularly pronounced for particle sizes <100 nm - and all wavelengths lie precisely within this range. QIDOSHA Bio+ Products.

Due to the small particle size of the active ingredients, sublingual absorption begins immediately after ingestion in the mouth. This leads to a immediate effect of the QIDOSHA Bio+ Products so that the active ingredients are detectable in the blood plasma after just 5 minutes. This is particularly important for active ingredients such as melatonin, where a rapid effect is desired.

While some manufacturers already offer products with increased bioavailability by combining the active ingredient with lipids (so-called "liposomal" or "micellar" products), the challenge here is not achieving very high bioavailability. immediately after production Achieving this is actually quite complicated. It's crucial to produce the solution in such a way that the bond between the active ingredient and the lipids remains stable over the long term and doesn't dissolve again after a short time. Otherwise, the expensive liposomal products will quickly revert to the bioavailability of a "standard vitamin tablet from the discount store."

Example: Liposomal coenzyme Q10 from a competitor: after centrifugation, clear separation of active ingredient and lipids is shown.:

Liposomal coenzyme Q10 produced with QIDOSHA Bio+ shows high stability even after centrifugation.:

We guarantee at least 24 months of long-term stability for all our products. QIDOSHA Bio+ Article. Stabilization is achieved through a monolayer of the natural emulsifier lecithin.

The so-called PDI value (polydispersity index) indicates the width of the size distribution of the active ingredient particles around the mean particle size. A value of 0 would mean that all particles are the same size. A PDI of less than 0.3 indicates a stable system.

D.h. The smaller the PDI, the more stable the system. (cf.) Edgar Acosta, Bioavailability of nanoparticles in nutrient and nutraceutical delivery, COCIS, 14, 1, 2009, 3-15).  Aggregation occurs primarily when small particles merge with larger particles. This is known as "Ostwald ripening." If all particles lie within a narrow size distribution, ripening is inhibited.

The particle size of our products is significantly below 100 nm. (Ex.: Coenzyme Q10: 58.7 nm, melatonin: 57.4), the PDI below 0.3 (Ex.: Coenzyme Q10: 0.295, melatonin: 0.288).

Bioavailability describes the amount and rate at which a drug is absorbed by the human body. It indicates the proportion of a substance that enters the systemic circulation, as opposed to the amount that is metabolized and excreted unused.

In short: Bioavailability indicates how quickly and over what period of time an active ingredient is absorbed by our body..

When we take dietary supplements or medications, we naturally want them to be effective. This is only possible with sufficiently high bioavailability. It's not enough to simply take a tablet, capsule, or powder and assume that the body is adequately supplied. The medication or dietary supplement must also have a correspondingly high bioavailability. Otherwise, the preparation remains ineffective – it cannot be sufficiently absorbed and utilized by the body and thus cannot exert its potential at the site of action, such as the heart or muscles.

Simply taking more won't help either. High bioavailability is more important and healthier than a high dose.

Behind this frequently asked question lies the idea that if, for example, one ingests 15 times the amount of the active ingredient of a preparation that is only 1/15 as bioavailable as a QIDOSHA Bio+ Product The goal is that, in the end, roughly the same amount of active ingredient should reach the cells.

However, this is a misconception. Several studies have demonstrated, using vitamin C as an example, that a daily dose of >200 mg of vitamin C taken orally (standard preparations) does not lead to any further increase in the amount of vitamin C in the blood; the additional amount is simply excreted. 200 mg of standard preparations results in approximately... 70 µmol/L of vitamin C in the blood. Further increases with increased vitamin C intake cannot be achieved with standard supplements.

However, when using a liposomal carrier system for vitamin C, the value of The blood level should be significantly increased to 70 µmol/L. For example, in a study by Davis et al., the administration of 4 g of vitamin C in liposomal form only 3 hours after the Intake to achieve a blood vitamin C level of 200 µmol/L was measured.

Sources:

• Lukas Prantl et al; Enhanced Absorption of Liposomal Packed Vitamin C Monitored by Ultrasound, May 2020
• M Levine et al.;

  Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance; April 1996

Dietary supplement with liposomal melatonin with increased bioavailability and selected plant extracts.