Everyone knows it. There are days when you hardly have an appetite and then there are days when you could eat continuously, although you are completely aware that you have actually eaten enough.
A whole range of hormones and hormone-like peptides are responsible for our feeling of hunger and satiety. Big players are insulin and leptin, but we can also influence others.
glucagon-like-peptide 1 (GLP-1)
GLP-1 is a peptide produced in the lower digestive tract and brain that causes the stomach to empty more slowly and makes you feel full longer.
Various human studies have shown an opposite effect to ghrelin. Fatty and high-energy food suddenly appears far less attractive under the influence of GLP-1.
GLP-1 is now available as a medication in various preparations and actually leads to an average weight loss of 4.5 kg in severe obesity. The problem, however, is that this effect is not sustainable, since there is no influence on the existing insulin resistance and GLP-1 actually stimulates the pancreas to release even more insulin, which is why the drug is also used in diabetes.
If it is stopped, the pounds come back and the loss is not great enough to achieve any actual health improvement. Some plant substances such as substances from the bitter orange stimulate the release of GLP-1 and can therefore be helpful in not feeling hungry on an energy-restricted diet and developing less appetite for counterproductive foods.
Substances that dock to the GLP-1 receptor in the body, such as bitter orange, can also be helpful. In the IN-SHAPE of QIDOSHA, bitter orange is cleverly combined with other stabilizing substances. It can be a helpful supplement both during an energy-reduced phase and especially afterwards.
Dr. Simone Koch
The L-carnitine is a carrier for the fats from food (after beta-oxidation) into the mitochondria and the also contained coenzyme Q10 is important as part of the respiratory chain in the mitochondria. As a result, ATP formation (cell energy) can be strengthened.