PureWay-C - real liposomal vitamin C – QIDOSHA

PureWay-C - real liposomal vitamin C

June 26, 2025from Patrick Linder

Vitamin C (ascorbic acid) is an essential, water-soluble micronutrient that plays a central role in numerous physiological processes, including immune function, collagen synthesis, and antioxidant defense. Despite its fundamental importance for human health, the therapeutic efficacy of conventional vitamin C is limited by its restricted bioavailability.. Ascorbic acid is absorbed via saturable transport mechanisms in the small intestine, meaning that at higher doses only a small percentage of the ingested amount actually enters the bloodstream.

Liposomal vitamin C formulations have established themselves as an innovative solution for these absorption limitations. By encapsulating vitamin C in lipid bilayers, the natural barriers to gastrointestinal absorption are bypassed, resulting in significantly improved bioavailability.This technological advancement opens up new therapeutic possibilities and makes higher cellular vitamin C concentrations possible without the typical gastrointestinal side effects of high oral doses.

Biochemical principles and mechanisms of action

Liposomal technology

Liposomes are microscopic, hollow vesicles made of phospholipid bilayers that structurally resemble cell membranes. This similarity allows liposomes to fuse with cell membranes and transport their contents directly into the cell interior. In the case of liposomal vitamin C, the ascorbic acid is encapsulated in the aqueous interior of the liposomes and thus protected from degradation in the gastrointestinal tract.

Liposomal encapsulation overcomes several absorption barriers: First, it protects vitamin C from oxidation and the acidic environment of the stomach. Second, it enables direct transport into the lymphatic system, bypassing the saturable sodium-dependent vitamin C transporters (SVCT1 and SVCT2) in the small intestine. Third, cellular uptake occurs via endocytosis and passive diffusion, allowing for significantly higher intracellular concentrations.

Pharmacokinetic advantages

Clinical studies have shown that liposomal vitamin C significantly increases and prolongs plasma concentrations of ascorbic acid. A randomized, double-blind crossover study with 27 healthy volunteers documented that 500 mg of liposomal vitamin C resulted in 27% higher maximum plasma concentrations (Cmax) and 21% higher area under the curve (AUC0-24) compared to conventional vitamin C. Additionally, significantly higher vitamin C concentrations were also observed in leukocytes (+20% Cmax, +8% AUC), which is particularly relevant for immune function.

Clinical evidence on bioavailability

The superior bioavailability of liposomal vitamin C has been demonstrated in several clinical human studies. In a controlled crossover study, Gopi et al. showed that liposomal vitamin C had a 1.77-fold higher bioavailability than non-liposomal vitamin C. Participants received identical doses under fasting conditions, and vitamin C levels were measured over 24 hours.

Another study documented a 30% increase in AUC and a 30% prolongation of elevated blood levels after 24 hours with liposomal vitamin C compared to the non-encapsulated form. This prolonged retention is therapeutically significant because it allows for a more continuous supply of vitamin C to the tissues.

Cellular uptake and tissue distribution

The improved bioavailability of liposomal vitamin C is reflected not only in plasma concentrations but also in its uptake by different cell types. In vitro studies with Caco-2 cells showed significantly higher permeability of liposomal vitamin C across the intestinal barrier. This improved absorption at the cellular level explains the clinically observed differences in systemic availability.

For the first time, ultrasound studies have directly visualized the improved intestinal absorption of liposomal formulations. The liposomes behave similarly to ultrasound contrast agents, allowing their passage through the gastrointestinal tract to be tracked.

Therapeutic applications

Immune system and infection defense

Vitamin C plays a central role in immune function by supporting leukocyte function, reducing inflammation, and modulating cytokines. Liposomal vitamin C offers particular advantages in this area, as its improved cellular uptake leads to higher concentrations in immune cells.

Clinical studies have shown that elevated leukocyte vitamin C levels following liposomal supplementation correlate with an improved immune response against infections. These findings are particularly relevant for immunocompromised patients or individuals at increased risk of infection.

Cancer therapy and oncological applications

The role of high-dose vitamin C in cancer therapy has attracted increasing scientific interest in recent years. Studies have shown that at sufficiently high concentrations, vitamin C can act selectively against cancer cells by promoting the formation of hydroxyl radicals and influencing various tumor-relevant signaling pathways.

Liposomal vitamin C offers the advantage in oncological applications that therapeutically relevant concentrations can be achieved orally without the gastrointestinal side effects of high intravenous doses. A study with liposomally encapsulated epirubicin and ascorbic acid demonstrated impressive antitumor activity in a breast cancer mouse model.

Preclinical studies suggest that liposomal vitamin C may also enhance the effectiveness of chemotherapy and radiation therapy. These synergistic effects are attributed to improved cellular uptake and antioxidant properties.

Wound healing and collagen synthesis

Vitamin C is an essential cofactor for prolyl hydroxylases, which are responsible for collagen synthesis and stabilization. A systematic review of the effects of vitamin C on wound healing showed that supplementation increased the likelihood of faster recovery by 3.94 times.

Liposomal vitamin C offers particular advantages in this area due to improved tissue distribution and higher local concentrations. Preclinical studies have shown that vitamin C increases the activity of collagen-secreting fibroblasts and stimulates type I collagen production.

Cardiovascular health

The antioxidant properties of vitamin C play an important role in protecting against cardiovascular disease. Liposomal vitamin C, with its improved bioavailability, can more effectively reduce oxidative stress and lower inflammatory markers.

Studies have shown that liposomal vitamin C supports heart function by reducing oxidative stress and improving vascular function. Its prolonged retention in the bloodstream allows for a more continuous antioxidant effect.

PureWay-C: The superior vitamin C formulation

· Unique composition and technology

O PureWay-C represents a revolutionary advancement in vitamin C supplementation and differs fundamentally from conventional liposomal formulations. This patented form combines ascorbic acid with lipid metabolites from triglycerides and citrus bioflavonoids to ensure superior absorption, distribution, and cellular uptake.

O The lipid metabolites in PureWay-C are derived from safe plant sources and are blended with ascorbic acid during the manufacturing process. These fatty acid metabolites act as ascorbic acid carriers, enhancing intestinal absorption and tissue distribution, and subsequently increasing bioavailability through improved cellular uptake kinetics.

· Clinical superiority over other forms of vitamin C

O The scientific evidence for the superiority of PureWay-C is supported by several clinical human studies. A study conducted at the University of Miami School of Medicine with healthy volunteers showed that PureWay-C resulted in the highest average serum vitamin C levels over a 24-hour period compared to ascorbic acid, calcium ascorbate, and Ester-C.

O The study documented that PureWay-C achieved statistically significantly higher serum levels than calcium ascorbate at all time points (1, 2, 4, and 6 hours after oral supplementation). Ester-C showed a smaller, but statistically significant, increase only at time points of 1 and 4 hours.

O Particularly noteworthy is the superior cellular uptake of PureWay-C. Studies at Adelphi University showed that two hours after treatment, human T lymphocytes treated with PureWay-C contained higher levels of vitamin C than any other treatment group studied. This 233% increase in cellular uptake compared to ascorbic acid explains its superior biological activity.

· Antioxidant and anti-inflammatory properties

O PureWay-C exhibits exceptional antioxidant properties that go beyond those of conventional vitamin C.In DPPH assays, PureWay-C demonstrated a near 100% reduction of free radicals at 20 μg/ml and an oxygen radical scavenging activity of over 1200 μM Trolox equivalents per gram.

O The IC50 value for PureWay-C was 5.58 μg/ml compared to 8.08 μg/ml for ester ascorbate, representing a 10.47% higher antioxidant efficacy. These superior antioxidant properties correlate with reduced inflammatory markers in clinical trials.

O Clinical studies have shown that PureWay-C has significantly stronger anti-inflammatory effects than other forms of vitamin C. Oral supplementation with PureWay-C resulted in a greater reduction in plasma C-reactive protein (CRP) and oxidized LDL levels compared to other vitamin C formulations.

O After 24 hours, CRP levels decreased by 15.6% and oxidized LDL by 8.4%. These anti-inflammatory effects are of particular clinical relevance, as chronic inflammation is associated with numerous diseases.

· Neurological and regenerative properties

O A unique aspect of PureWay-C is its superior ability to support neurological function. Clinical studies conducted at Adelphi University demonstrated that PureWay-C has a superior capacity to protect against neurodegenerative diseases compared to other forms of vitamin C.

O In vitro, PureWay-C was more active and effective than ascorbic acid, calcium ascorbate, and Ester-C in stimulating neurite outgrowth, fibroblast wound healing activity, and protecting the immune system from xenobiotic-induced inflammatory mechanisms. Nerve regeneration was promoted 12 times more efficiently, wound healing was stimulated 3 times more efficiently, and the immune system was protected 2.5 times better against toxins.

Liposomal PureWay-C: The next stage of evolution

Another innovation is the combination of PureWay-C with liposomal technology. Liposomal PureWay-C utilizes LiposoMax™ technology to ensure uniform liposomal encapsulation and guarantee true liposomal technology.

This combination unites the superior properties of PureWay-C with the advantages of liposomal delivery technology. The result is a formulation with maximized absorption, rapid results, and the highest available bioavailability.

Safety profile and compatibility

Liposomal vitamin C has an excellent safety profile and is generally well tolerated. The most commonly reported side effects are mild and occasionally include gastrointestinal discomfort such as nausea, diarrhea, or stomach cramps, particularly at higher doses.

Compared to conventional vitamin C, liposomal vitamin C exhibits significantly better gastrointestinal tolerability. Liposomal encapsulation reduces direct effects on the gastric mucosa and allows for higher doses to be taken without the typical digestive discomfort.

Certain groups of people should exercise particular caution when taking liposomal vitamin C. Individuals with kidney problems have an increased risk of kidney stones with high doses of vitamin C. Individuals with hemochromatosis should seek medical advice due to the increased iron absorption caused by vitamin C.

Pregnant women should adhere to the recommended dosages and consult a doctor before starting any supplementation.

Application recommendations

For optimal absorption, liposomal vitamin C should preferably be taken on an empty stomach. In sensitive individuals, taking it with a meal may improve tolerability without significantly affecting its effectiveness.

It is recommended to take the medication early in the day to avoid potential sleep disturbances. At higher doses, dividing the dose throughout the day may improve tolerability.

Conclusion

Liposomal vitamin C represents a significant advancement in vitamin C supplementation, offering new therapeutic possibilities through its improved bioavailability. Clinical evidence clearly demonstrates the superiority of liposomal formulations over conventional vitamin C in terms of absorption, cellular uptake, and therapeutic efficacy.

PureWay-C stands out as the most advanced vitamin C formulation, achieving 233% higher cellular retention through its unique combination of lipid metabolites and citrus bioflavonoids. Clinical studies clearly demonstrate the superiority of PureWay-C over all other available forms of vitamin C.

The combination of PureWay-C with liposomal technology represents the pinnacle of vitamin C innovation, offering maximum absorption with optimal tolerability. This development opens up new perspectives for the therapeutic application of vitamin C in the prevention and treatment of various diseases.

For users who want to optimally benefit from the diverse health advantages of vitamin C, liposomal PureWay-C represents the most scientifically sound and effective option. Ongoing research will open up further areas of application and further strengthen the position of liposomal vitamin C as an essential therapeutic tool.

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Source of the photograph: https://www.woon-magazine.nl/

PureWay-C - real liposomal vitamin C

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