Bromelein - Origin

The pineapple (Ananas comosus) belongs to the bromeliad family (Bromeliaceae). It originated in South America and is now cultivated worldwide in tropical regions (it requires temperatures of at least 20°C).

Bromelain is an extract from pineapple that v.aBromelain is extracted from the stems because it exhibits higher enzymatic activity there than the bromelain found in the fruit. The fresh stems are crushed, peeled, and pressed. The bromelain is then extracted from the resulting juice. It is important to note that bromelain is present in fresh pineapple but not in canned pineapple, because enzymes are destroyed by heating above 50°C.

Bromelain is an enzyme mixture whose most important component is a proteolytic thiol fraction. Other components include a peroxidase, acid phosphatase, several protease inhibitors, and calcium.

Both papain and bromelain are enzymes. Enzymes consist of protein chains (amino acids) and are also known as biocatalysts because they stimulate many important biochemical reactions within the body. Bromelain and papain belong to the group of proteases, whose function is to break down proteins. Due to its ability to break down proteins, bromelain is used not only in naturopathy but also, for example, in the food industry to tenderize meat and in the beverage industry to prevent protein-induced cloudiness.

Use and mode of action

Bromelain's ability to break down proteins is also the basis for its therapeutic use: Most injuries caused by trauma are accompanied by painful swelling, which in turn is due to an increased protein content within the injured tissue. In the case of injury, protein components enter the injured tissue from the bloodstream and cause swelling. This is where bromelain comes into play, preventing swelling by breaking down these protein components. Furthermore, bromelain has an effect on... counteract inflammation and improves blood circulation in the inflamed tissue, so that the Healing accelerated becomes.

The following statement was also published in the German Pharmacists' Journal:
"Bromelain is suitable for treating swelling after surgeries and injuries, such as sports injuries that are accompanied by swelling. Bromelain supports the breakdown and removal of swelling-causing proteins. It reduces swelling and thus relieves pain by reducing pressure in the injured area. It also significantly speeds up the healing of bruises." Source: https://www.deutsche-apotheker-zeitung.de/news/artikel/2014/05/06/bromelain-wirkstoff-aus-der-ananas

Furthermore, a study by German scientists from 2012 suggests that positive effect from Bromelain to our immune system This study investigated the effects of two doses of bromelain on inflammation-related cytokines in a placebo-controlled, 3× crossover, single-dose clinical trial. It was demonstrated for the first time that bromelain modulates the cellular responses of lymphocytes following oral administration. The immunomodulatory effect of bromelain observed in this study is thought to be part of its known mechanism of action. anti-inflammatory activities Further research is needed to verify the relevance of these findings to a compromised immune system. https://pubmed.ncbi.nlm.nih.gov/22517542/

The pineapple is, right after the papaya, one of the most alkaline fruits and thus contributes to a Regulation of our acid-base balance at.Bromelain works anticoagulant, by helping to break down a protein in the blood that can reduce blood circulation (fibrin).

“According to studies, bromelain possesses various effectsBromelain has an inhibitory effect on swelling after injuries or surgeries (edema) and influences blood clotting by, among other things, prolonging bleeding time and preventing platelet aggregation. Furthermore, this enzyme mixture has anti-inflammatory properties and, due to its protein-splitting abilities, can support digestion (for example, in cases of pancreatic diseases, as the pancreas normally produces digestive enzymes). Bromelain's effects on various types of cancer and inflammatory rectal changes, which may be precancerous, have also been investigated, with positive results. However, this pineapple compound is not suitable as a sole therapy for cancer.Source: https://www.netdoktor.de/medikamente/bromelain/

Papain - Origin

The papaya (Carica papaya) belongs to the genus Carica. It originally comes from the American tropics; its name comes from the language of the Arawak Indians, who have long used the papaya as a medicinal plant. At the beginning of the 16th century, the Spanish began to introduce the papaya and cultivate it in the Antilles and the Philippines.

At the end of the 20th century, he succeeded for the first time in extracting the most important enzyme of the papaya tree from its milky sap: papain. Papin is a peptidase composed of more than 200 amino acids that can cleave peptides. It serves as a defense mechanism for the papaya tree against microorganisms.

It should be noted that green, unripe papayas contain about 5000% more papain than ripe papayas.

Papain, like bromelain, is used in the food industry to tenderize meat: it breaks down the bonds between proteins that hold the connective tissue fibers of the meat together. Papain is also used in the textile industry to prevent wool and silk from felting and shrinking.

Benefits and mode of action

Due to the property described above of cleaving peptide bonds, papain facilitates the conversion of dietary proteins to amino acids and This promotes digestion.

Papain will v.aIt is used for inflammation, sports injuries, and insect bites, as it reduces the Wound healing and regeneration processes activated and intensified.

Papain could lead to Prevention and treatment of autoimmune diseases It contributes to this, as in combination with other proteolytic enzymes such as bromelain it stimulates the formation of interleukins (endogenous messenger substances of the cells of the immune system) and tumor necrosis factor (regulates the activity of various immune cells).

Since papain contributes to the breakdown of fibrin and fibrinogen in the blood, it prevents platelets from clumping together and thus counteracts the formation of Thrombosis and vascular diseases in contrast to.

Papain can enhance the oral bioavailability of curcumin and is only absorbed by 6 to 10% through the healthy intestinal mucosa of an adult, so it should be taken regularly.

Legal consumer information:

German and European law aims to protect consumers from potentially misleading claims about the effects of certain products. The statements made here refer to the original Ayurvedic and Traditional Chinese Medicine (TCM) texts. This millennia-old, traditional knowledge is based on experiences passed down from generation to generation.It is not being claimed that the products described here have any effect in the sense of Western medicine. All products are dietary supplements; they are not medications and have no medicinal effect. If you are ill and require medical attention, please consult your doctor or pharmacist.