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Everyone knows the feeling. There are days when you barely have an appetite, and then there are days when you could eat non-stop, even though you know perfectly well that you've already eaten enough.
A whole range of hormones and hormone-like peptides are responsible for our feelings of hunger and satiety. Insulin and leptin are major players, but we can also influence others.
For example:
Glucagon-like peptide 1 (GLP-1)
GLP-1 is a peptide produced in the lower digestive tract and brain, leading to slower gastric emptying and a longer feeling of satiety.
Several human studies have shown an effect opposite to that of ghrelin. Fatty and energy-rich foods suddenly appear far less appealing under the influence of GLP-1.
GLP-1 is now available in various formulations as a medication and does indeed lead to an average weight loss of 4.5 kg in cases of severe obesity. The problem, however, is that this effect is not sustainable, as it does not address existing insulin resistance and GLP-1 actually stimulates the pancreas to produce even more insulin, which is why the drug is also used to treat diabetes.
If the medication is discontinued, the weight returns, and the weight loss is not significant enough to achieve a real improvement in health. Some plant compounds, such as those found in bitter orange, stimulate the release of GLP-1 and can therefore be helpful in preventing hunger pangs and reducing cravings for unhealthy foods while following a calorie-restricted diet.
Substances that bind to the GLP-1 receptor in the body can also be helpful, such as... z.BThe bitter orange. In IN-SHAPE by QIDOSHA Bitter orange is cleverly combined with other stabilizing substances. It can be a helpful supplement both during a period of reduced energy intake and especially afterwards.
Our author:
Dr. Simone Koch
Addition
The L-Carnitine is a carrier for dietary fats (after beta-oxidation) into the mitochondria and the also contained Coenzyme Q10 It is important as part of the respiratory chain in the mitochondria. As a result, ATP production (cellular energy) can be enhanced.