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Everyone knows it. There are days when you have barely any appetite, and then there are days when you could eat nonstop, even though you're fully aware that you've actually eaten enough.
A whole range of hormones and hormone-like peptides are responsible for our feelings of hunger and satiety. Insulin and leptin are major players, but we can also influence others.
For example:
Glucagon-like peptide 1 (GLP-1)
GLP-1 is a peptide produced in the lower digestive tract and brain that leads to slower stomach emptying and a longer feeling of satiety.
Various human studies have shown an opposite effect to ghrelin. Fatty and energy-rich foods suddenly appear far less appealing under the influence of GLP-1.
GLP-1 is now available as a medication in various formulations and actually leads to an average weight loss of 4.5 kg in cases of severe obesity. The problem, however, is that this effect is not sustainable, as it does not affect existing insulin resistance and GLP-1 actually stimulates the pancreas to secrete even more insulin, which is why the medication is also used for diabetes.
If you stop taking it, the weight will return, and the weight loss won't be significant enough to achieve a real health improvement. Some plant substances, such as bitter orange, stimulate the release of GLP-1 and can therefore be helpful in reducing hunger and developing less of an appetite for counterproductive foods on an energy-restricted diet.
Substances that bind to the GLP-1 receptor in the body can also be helpful, such as z.B. the bitter orange. In IN-SHAPE by QIDOSHA Bitter orange is cleverly combined with other stabilizing substances. It can be a helpful supplement both during a phase of reduced energy and especially afterward.
Our author:
Dr. Simone Koch
Addition
The L-carnitine is a carrier for the fats from food (after beta-oxidation) into the mitochondria and the also contained Coenzyme Q10 is important as part of the respiratory chain in the mitochondria. As a result, ATP production (cellular energy) can be enhanced.