Vitamins

Unlike vitaminoids, vitamins cannot be produced by our bodies, so they must be constantly supplied from outside. They ensure the proper functioning of the metabolism, strengthen the immune system, and are essential for the development of cells, blood cells, bones, and teeth. They also regulate the utilization of nutrients such as carbohydrates, proteins, and minerals.

A distinction is made between fat-soluble and water-soluble vitamins. Vitamins A, D, E, and K are fat-soluble vitamins, whereas vitamins C and B, for example, are water-soluble. Therefore, vitamins D3 and K2 should always be taken in a fat solution.

Vitamin K

Vitamin K owes its name to the fact that it is involved in blood clotting (= coagulation). Vitamin K is divided into Vitamin K1 (phylloquinone) and K2 (menaquinone)Vitamin K1 is found v.a. in the leaves of green plants, where it is needed for photosynthesis (e.g., in spinach and broccoli). Vitamin K2, on the other hand, is produced by microorganisms and is therefore found v.a. in fermented foods such as sauerkraut or some cheeses. A certain amount of vitamin K2 is also produced in the human intestine. It can i.d.R. only a very small part of the daily vitamin K2 requirement can be covered through food.

That studies and proven positive effects for the organism to date v.a. for vitamin K2 present (for K1 is v.a. known to activate the coagulation factor prothrombin in the liver), is likely due to its significantly higher bioavailability and metabolism compared to vitamin K1. The latter is only ~10% absorbed through the intestinal mucosa – the remainder is broken down in the liver. In contrast, vitamin K2 is almost 100% absorbed because, unlike K11, it does not remain in the liver but is absorbed from there into the bloodstream and tissues.

A possible Vitamin K2 deficiency In addition to diet, it can also be due to disturbed intestinal flora This may be due to the fact that some vitamin K2 is produced in the intestines. A disturbance in the intestinal flora can be caused by certain diseases such as Crohn's disease or by taking antibiotics, antiepileptic drugs, or laxatives.

It should be noted that vitamin K2 exists in various variants that differ in the length of their chemical side arms (these are referred to as MK4 (menaquinone-4) to MK13 – with MK4 and MK7 being the best known and best-researched variants to date) or in their spatial structure (cis or trans variant). Cis isomers arise. v.a. when vitamin K2 is produced synthetically and not obtained through natural fermentation.

The most effective form of K2 vitamins is Menaquinone-7, also called MK7, because it remains available in the blood for over 72 hours, while the majority of MK4 is excreted after just a few hours due to poorer binding in the blood. Since the body only trans variant To ensure that the product can be used effectively, it is essential to pay attention to this declaration when comparing products. The higher the trans content, the better. If the trans content is greater than 98%, the product can be called "all-trans."

Vitamin D3

Vitamin D3 requires sunlight to be synthesized by the body. This applies to 80–90% of vitamin D3, as the average German only absorbs 2.5 µg of vitamin D through food (e.g., fish, eggs, or mushrooms).

Accordingly, a Vitamin D3 deficiency v.a. from low sunlight exposure; this is in our latitudes v.a. in the months October to March.Pregnancy, menopause, or puberty can also contribute to a vitamin D3 deficiency due to hormonal changes. Finally, with age, the body's ability to synthesize vitamin D3 declines, so vitamin D3 deficiency is more common in older people than in younger people. v.a. is therefore critical because cancer and many other chronic diseases occur more frequently during this phase of life. It therefore makes sense that naturopathy encourages us to "get out into the fresh air." There, we absorb solar energy even when the sky is overcast.

According to studies by the Robert Koch Institute from 2016, only 38.4% of adults in Germany are adequately supplied with vitamin D. (Source: https://edoc.rki.de/handle/176904/2492)

In the Journal of Health Monitoring 2016 1(2) of the Robert Koch Institute on pages 36 ff states:

"One important function of vitamin D is its involvement in bone metabolism. Among other things, it promotes the absorption of calcium from the small intestine and the hardening of bones. A severe and persistent vitamin D deficiency can lead, among other things, to softening of bones and deformities of the skeleton and thus to rickets in infancy and childhood and to osteomalacia in adulthood. In old age, vitamin D deficiency can also contribute to the development of osteoporosis. In recent years, observational studies have also found links between low vitamin D levels and various chronic diseases such as type 2 diabetes mellitus, cardiovascular disease, and cancer. [...] Due to the fact that only a few foods, such as edible fish with a high fat content or mushrooms, contain sufficient amounts of vitamin D, the body's own synthesis contributes the largest part to the supply, with an estimated share of 80% to 90%. The radiation required for this occurs year-round only in regions below the 35th parallel. At higher latitudes, the intensity and duration of adequate radiation decreases, and vitamin D production becomes seasonally dependent. This also applies to Germany, which lies between the 47th and 55th parallels. […] Older people and those who rarely spend time outdoors or only do so with their skin covered (e.g., due to need for care or religious or cultural reasons), or those with dark skin, are at increased risk of vitamin D deficiency. This also includes people who have chronic gastrointestinal, liver, or kidney diseases, or who take medications that impair vitamin D metabolism (e.g., antiepileptics or cytostatics)."

As well as Vitamin K also contains vitamin D in different variants. That v.a. the Vitamin D3 use in food supplements is probably due to the fact that it increases vitamin D levels by approx. twice as effective increases as much as vitamin D2. This is probably due to the better absorption capacity and longer retention of vitamin D3 in the bloodstream (source: https://pubmed.ncbi.nlm.nih.gov/28679555/)

Benefits and mode of action

following Health Claims are now permitted for vitamins K and D, provided that certain requirements v.a. regardingthe dosage are met:

• Vitamin D contributes to the normal function of the immune system
• Vitamin D has a function in cell division
• Vitamin D contributes to the normal absorption/utilization of calcium and phosphorus
• Vitamin D contributes to normal calcium levels in the blood
• Vitamin D contributes to the maintenance of normal bones
• Vitamin D contributes to the maintenance of normal muscle function
• Vitamin D contributes to the maintenance of normal teeth
• Vitamin K contributes to normal blood clotting
• Vitamin K contributes to the maintenance of normal bones

Vitamin K2 is required for Activation of the bone protein osteocalcinAn increased level of non-activated osteocalcin leads to lower bone density and thus to an increased risk of fractures. Vitamin K2 deficiency Too little calcium is stored in the bones and a osteoporosis Studies have shown that vitamin K2 can significantly reduce bone loss in osteoporosis patients (from a dose of 180 µg of vitamin K2 per day). Vitamin D3 administered, the two vitamins act synergistically and the Increased bone density However, osteoporosis should not be treated with high doses of vitamin D3 alone.

An important role is played by Vitamin K in relation to calciumCalcium is essential for strong bones and teeth; however, deposits in the blood vessels, which pose a risk of coronary heart disease, are extremely undesirable. This is where vitamin K2 plays a crucial role, making calcium usable by the body and activating certain proteins such as osteocalcin and the matrix GLA protein. Without vitamin K, these proteins remain ineffective and cannot perform their function in the body. Osteocalcin regulates the mineralization of bones and teeth and ensures that calcium is absorbed into the bones. The matrix GLA protein ensures that calcium is not deposited in the blood vessels, but rather binds it and transports it away.
This is exactly the mechanism by which K2 prevents osteoporosis and arteriosclerosis:

At a Vitamin D deficiency take the bone-building cells (osteoblasts) and bone volume decreases. This can be corrected by taking vitamin D, and more osteoblasts are formed again. However, vitamin D also promotes the maturation of bone-degrading cells (osteoclasts), thus indirectly promoting bone loss. This effect of vitamin D is suppressed by the simultaneous intake of vitamin K2. Furthermore, as described above, vitamin K2 is essential for the body's production of osteocalcin, a protein involved in bone mineralization.

The so-called “Rotterdam Study” has shown that people who have consumed larger amounts of vitamin K2 over 10 years have significantly less calcium deposits in the arteries and generally a significantly better cardiovascular health had than others.

The sunbathing for example, in the case of tuberculosis patients or people who had to work underground, used medicallySince 1980, it has been known that sunlight has a positive effect even on serious illnesses: Cedric Garland, an epidemiologist at the University of California, showed in a study that many types of cancer were far less common in regions where the sun shone more frequently. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470481/ Later, international population studies confirmed this connection.

Qidosha products

The QIDOSHA product combines the high-quality vitamins D3 and K2 in ideal dosages in one preparation. It contains MK7 (menaquinone-7), the form of vitamin K2 that has the highest bioavailability, is more fat-soluble, and circulates in the blood the longest. The trans content, which is relevant for effectiveness, is greater than 98%, making it an "all-trans" product.

Unlike other dietary supplements, we chose oil as the delivery form for vitamins K2 and D3 because both K2 and D3 are fat-soluble vitamins, and studies such as the one by Traub et al. from 2014 suggest higher absorption by the body with drops/oil as a delivery form than with tablets or capsules.

Since vitamins K2 and D3 are interdependent, their dosage should always be coordinated. Since K2 activates the proteins formed by vitamin D (s.o.), it is conceivable that a higher vitamin D supply to the body could easily lead to a vitamin K2 deficiency, as more vitamin K is used for protein activation. Some studies have shown that a generally beneficial, high vitamin D level can actually increase the risk of bone fractures if there is a simultaneous vitamin K deficiency. Therefore, we do not offer monopreparations containing only one of the two vitamins, but rather this combination preparation with a perfectly balanced combination of the two vitamins.