Vitamins

Vitamins – unlike so-called vitaminoids – cannot be produced by our bodies, which is why they must be constantly supplied from external sources. They ensure that metabolism functions properly, strengthen the immune system, and are essential for the formation of cells, blood cells, bones, and teeth. They also regulate the utilization of nutrients such as carbohydrates, proteins, and minerals.

Vitamins are classified as either fat-soluble or water-soluble. Vitamins A, D, E, and K are fat-soluble, while vitamins C and B, for example, are water-soluble. Therefore, vitamins D3 and K2 should always be taken in a fat-soluble solution.

Vitamin K

Vitamin K owes its name to the fact that it is involved in blood clotting (coagulation). Among the K vitamins, a distinction is made between different types. Vitamin K1 (phylloquinone) and K2 (menaquinone)Vitamin K1 is found v.aVitamin K is found in the leaves of green plants, where it is needed for photosynthesis (e.g., in spinach and broccoli). Vitamin K2, on the other hand, is produced by microorganisms and is therefore found in the leaves of plants. v.a. in fermented foods such as sauerkraut or some cheeses. A certain amount of vitamin K2 is also produced in the human gut. It can i.d.ROnly a very small part of the daily vitamin K2 requirement can be covered by food.

That studies and proven positive effects for the organism to date v.a. for vitamin K2 present (for K1 is v.aVitamin K2 (known to activate the coagulation factor prothrombin in the liver) is likely due to its significantly higher bioavailability and metabolism compared to vitamin K1. Only about 10% of vitamin K1 is absorbed through the intestinal mucosa – the rest is broken down in the liver. In contrast, vitamin K2 is absorbed almost 100% because, unlike K11, it does not remain in the liver but passes from there into the bloodstream and tissues.

One possible Vitamin K2 deficiency In addition to diet, one can also focus on a disturbed intestinal flora This could be due to the fact that some vitamin K2 is produced in the gut. A disruption of the intestinal flora can be caused by certain diseases such as Crohn's disease, or by the use of antibiotics, antiepileptic drugs, or laxatives.

It should be noted that vitamin K2 exists in various forms, differing in the length of their chemical side chains (these are designated MK4 (menaquinone-4) to MK13 – with MK4 and MK7 being the best-known and most thoroughly researched forms to date) or in their spatial structure (cis or trans). Cis isomers are formed v.a...then, when the K2 vitamin is produced synthetically and not obtained through natural fermentation.

The most effective form of the K2 vitamins is considered to be... Menaquinone-7, also called MK7, because it remains available in the blood for over 72 hours, while the majority of MK4 is excreted after just a few hours due to poorer binding in the blood. Since the body only needs the trans variant When comparing products, it is essential to pay close attention to this declaration. The higher the trans content, the better. Products with a trans content greater than 98% can be labeled "all-trans".

Vitamin D3

Vitamin D3 requires sunlight to be synthesized by the body. This applies to 80–90% of vitamin D3, as the average German only consumes 2.5 µg of vitamin D through food (e.g., fish, eggs, or mushrooms).

Accordingly, a Vitamin D3 deficiency v.a. from low sunlight exposure; this is the case in our latitudes v.aThis is the case in the months of October to March.However, pregnancy, menopause, and puberty can also contribute to a vitamin D3 deficiency due to hormonal changes. Finally, the body's ability to synthesize vitamin D3 declines with age, so vitamin D3 deficiency is more common in seniors than in younger people. This is v.aThis is therefore critical, as cancer and many other chronic diseases are more common during this phase of life. It makes sense, then, that naturopathy insists on getting "out into the fresh air." Because there, even on cloudy days, we absorb solar energy.

According to studies by the Robert Koch Institute from 2016, only 38.4% of adults in Germany have sufficient vitamin D levels.(Source: https://edoc.rki.de/handle/176904/2492)

In the Journal of Health Monitoring 2016 1(2) of the Robert Koch Institute on pages 36 ff it states:

“An important function of vitamin D is its involvement in bone metabolism. Among other things, it promotes the absorption of calcium from the small intestine and the hardening of bones. Severe and persistent vitamin D deficiency can lead to bone softening and skeletal deformities, resulting in rickets in infancy and childhood, and osteomalacia in adulthood. In old age, a vitamin D deficiency can also contribute to the development of osteoporosis. In recent years, observational studies have also found links between low vitamin D levels and various chronic diseases such as type 2 diabetes, cardiovascular disease, and cancer. [...] Because only a few foods, such as fatty fish or mushrooms, contain sufficient amounts of vitamin D, endogenous synthesis accounts for the largest share, estimated at 80% to 90%. The radiation required for this synthesis is only available year-round in regions below the 35th parallel. At higher latitudes, the intensity and duration of adequate radiation decrease, and vitamin D production becomes dependent on the season. This also applies to Germany, which lies between the 47th and 55th parallels. […] Older people, as well as those who rarely go outdoors or only with their skin covered (e.g., due to needing care or religious/cultural reasons), or who have dark skin, are at increased risk of vitamin D deficiency. This also includes people with chronic gastrointestinal, liver, or kidney diseases, or those taking medications that impair vitamin D metabolism (e.g., antiepileptics or cytostatics)."

Likewise Vitamin K also contains vitamin D in various versions. That v.a. the Vitamin D3 use The fact that it is found in dietary supplements is probably due to the fact that it raises vitamin D levels by approximately... twice as effective increases, similar to vitamin D2. This is likely due to the better absorption capacity and longer retention of vitamin D3 in the bloodstream (Source: https://pubmed.ncbi.nlm.nih.gov/28679555/)

Benefits and mode of action

following Health Claims are now permitted for vitamins K and D, provided certain requirements are met v.a. regardingThe dosage requirements are met:

• Vitamin D contributes to the normal function of the immune system.
• Vitamin D plays a role in cell division.
• Vitamin D contributes to the normal absorption/utilization of calcium and phosphorus.
• Vitamin D contributes to normal blood calcium levels.
• Vitamin D contributes to the maintenance of normal bones.
• Vitamin D contributes to the maintenance of normal muscle function
• Vitamin D contributes to the maintenance of normal teeth.
• Vitamin K contributes to normal blood clotting.
• Vitamin K contributes to the maintenance of normal bones.

Vitamin K2 is needed for Activation of the bone protein osteocalcinElevated levels of non-activated osteocalcin lead to lower bone density and thus an increased risk of fractures. In the case of a Vitamin K2 deficiency Too little calcium is stored in the bones, and this can lead to... osteoporosis Studies have shown that vitamin K2 can significantly reduce bone loss in osteoporosis patients (from a dose of 180 µg of vitamin K2 per day). If taken concurrently Vitamin D3 When administered, the two vitamins act synergistically and the Increased bone density However, osteoporosis should not be treated with high doses of vitamin D3 alone.

An important role is played Vitamin K in relation to calciumCalcium is essential for strong bones and teeth; however, calcium deposits in blood vessels are highly undesirable, increasing the risk of coronary artery disease. Vitamin K2 plays a crucial role here, making calcium usable for the body and activating certain proteins such as osteocalcin and matrix Gla protein. Without vitamin K, these proteins are ineffective and cannot perform their functions. Osteocalcin regulates the mineralization of bones and teeth, ensuring that calcium is absorbed into the bones. Matrix Gla protein ensures that calcium is not deposited in the blood vessels, but rather binds and transports it away.
This is exactly the mechanism by which K2 prevents osteoporosis and arteriosclerosis:

At a Vitamin D deficiency take the bone-building cells (osteoblasts) from and bone volume decreases. This can be corrected by taking vitamin D, which then leads to the formation of more osteoblasts. However, vitamin D also promotes the maturation of bone-resorbing cells (osteoclasts) and thus indirectly contributes to bone loss. This effect of vitamin D is suppressed by the simultaneous intake of vitamin K2. Furthermore, as described above, vitamin K2 is essential for the body's own production of osteocalcin, a protein involved in bone mineralization.

The so-called “Rotterdam Study” has shown that people who have consumed larger amounts of vitamin K2 over 10 years have significantly fewer calcium deposits in their arteries and generally a significantly improved immune system. improved cardiovascular health had more than others.

This was already established earlier sunbathing for example, in the case of tuberculosis patients or people who had to work underground, medically usedSince 1980, it has been known that sunlight has a positive effect even on serious illnesses: Cedric Garland, an epidemiologist at the University of California, showed in a study that many types of cancer were far less common in regions where the sun shone more frequently. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470481/ Later, international population studies confirmed this correlation.

Qidosha products

The QIDOSHA product combines the high-quality vitamins D3 &Vitamin K2 in an ideal dosage in one preparation. It contains MK7 (menaquinone-7), the form of vitamin K2 with the highest bioavailability, greater fat solubility, and the longest duration of blood circulation. The trans fraction, relevant for efficacy, is greater than 98%, making it an "all-trans" product.

Unlike other dietary supplements, we have chosen oil as the dosage form for vitamins K2 and D3, since both K2 and D3 are fat-soluble vitamins and studies such as that by Traub et al. from 2014 suggest that drops/oil as a dosage form result in higher absorption by the body than tablets or capsules.

Since vitamins K2 and D3 are interdependent, their dosages should always be coordinated. Because K2 activates the proteins produced by vitamin D (s.oIt is conceivable that a higher vitamin D supply to the body could easily lead to a vitamin K2 deficiency, as more vitamin K is used for protein activation. Some studies have shown that a generally beneficial high vitamin D level can actually increase the risk of bone fractures if there is a simultaneous vitamin K deficiency. Therefore, we do not offer single-vitamin supplements containing only one of the two vitamins, but rather this combination product with a perfectly balanced ratio of both vitamins.