WHAT EXACTLY IS CHLORELLA?
Unlike spirulina and AFA algae, chlorella algae have a cell nucleus, making chlorella a microalgae. Spirulina and AFA, on the other hand, are just bacteria (so-called cyanobacteria), although they are often referred to as "microalgae."
Although the chlorella algae is tiny, it is one of the most highly developed organisms and has managed to survive for more than two million years despite all the changes in its living conditions. This is probably the reason why scientists are so interested in this type of algae and why there are now numerous scientific studies on its health effects.
Another special feature of the Chlorella algae is its high chlorophyll content, which is reflected in its deep green colour and which in this concentration has not yet been measured in any other plant. In terms of its chemical structure, chlorophyll is almost identical to the human blood pigment hemoglobin.
NUTRIENTS IN CHLORELLA ALGAE
Vitamin B12 in Chlorella algae
Chlorella algae is a plant-based alternative to supplying vitamin B12 for vegans and vegetarians: 100 g of dried algae contain around 25-100 μg of vitamin B12. Unlike spirulina, chlorella mainly contains real vitamin B12 and not so-called vitamin B12 analogues. These are chemically similar to vitamin B12 and bind to the same transport molecules in the body, but have no effect. Chlorella is therefore the only algae that is suitable for substituting vitamin B12.
Other vitamins, trace elements and minerals in Chlorella
Chlorella contains all water-soluble vitamins (B vitamins and vitamin C) and fat-soluble vitamins (vitamin A, D, E and K) in a natural combination. The chlorella algae also contains the minerals calcium, magnesium, potassium and sodium as well as the trace elements iron, zinc, manganese, copper and selenium. Important for Graves' disease and Hashimoto's patients with iodine sensitivity: since chlorella is a freshwater algae, it is almost iodine-free.
For example, a study from 2010 was able to show that, due to the iron, vitamin B12 and folic acid it contains, the risk of anemia in pregnant women can be significantly reduced by taking 6 g of chlorella per day.
Chlorella as a protein source
Microalgae are one of the most important plant-based sources of protein. The protein content of dried Chlorella vulgaris is over 50%, which is higher than that of fish, chicken or beef.
In addition, the biological value, i.e. the proportion of the ingested protein that can be converted into the body's own protein and thus made available to the body, of the proteins from the chlorella algae is 88.
However, since chlorella is usually only taken in small amounts, little protein is absorbed in absolute terms. Nevertheless, chlorella can help to cover protein requirements: a daily dose of 7 g of chlorella provides 4 g of protein. For a 60 kg person who wants to consume the officially recommended 0.8 g of protein per kg of body weight, this would already be a good 8% of the protein requirement.
Chlorella regulates carbohydrate metabolism
Chlorella accelerates the transport of glucose into the liver and muscle cells, so that the energy obtained from it is available noticeably faster. This fact is particularly interesting for athletes, among others.For these reasons, chlorella supplementation has also proven effective in diabetes mellitus.
Chlorella is rich in detoxifying fiber
The cell wall of chlorella contains a wealth of fiber, which enters the intestine undigested and stimulates intestinal activity. Toxins and other harmful substances in the intestinal fluid are bound by the fiber and excreted in the stool.
fatty acids in chlorella
The fat content of the dried algae is 12%, but can be more than 30% depending on cultivation and processing.
Chlorella provides more than 30 fatty acids, one third of which are saturated, one third unsaturated and one third polyunsaturated fatty acids. Together, they help to ensure that every cell in the body remains stable, but still flexible and therefore healthy. Capric and lauric acid are worth mentioning among the saturated fatty acids, as they can kill bacteria, viruses and intestinal parasites. The high amounts of oleic acid (unsaturated fatty acid) contained in it have a preventive effect on various types of cancer and can also prevent strokes and heart attacks.
Chlorophyll in the microalgae Chlorella
The high chlorophyll content of the microalgae is responsible for its green color and has anti-carcinogenic effects on humans. Chlorophyll is also known for its detoxifying properties.
CURRENT STUDIES ON POSSIBLE APPLICATIONS OF CHLORELLA ALGAE
detoxification
- Chlorella is characterized by a variety of detoxifying ingredients. In addition to the chlorophyll mentioned above, the algae contains a unique mix of cell-protecting and detoxifying carotenoids (e.g. lycopene), glycoproteins (see CGF and CVE) and sporopollein (a highly detoxifying component of the chlorella cell wall). Chlorella also contains protectonien and de-noxilipidnin:
- Protectonia are storage proteins and are among the phyto-chelatins that are formed by the chlorella itself. On the one hand, they have a strong antioxidant effect, and on the other hand, they form an indissoluble bond with heavy metals (chelate formation), which are then easily excreted as a complex via the intestine. The substance de-noxilipidnin has a similar detoxifying effect. In addition to heavy metals, it also binds organic toxins and neutralizes them.
- For ethical reasons, there are almost exclusively animal-based studies on the connection between heavy metal poisoning and chlorella. In one of these studies, chlorella showed a kidney-protective effect in rats with cadmium poisoning. The kidney values in the blood improved and the protein excretion in the urine, which is a marker for kidney health, decreased.
- Chlorella can be used to support detoxification due to its heavy metal binding properties (chelate formation). In animal experiments, the microalgae also proved to be beneficial in cases of mercury poisoning in the mother during pregnancy. Chlorella prevented the transport of methylmercury to the fetus and thus protected the unborn child from poisoning. In addition, less mercury was deposited in the brains of the mothers in the chlorella group than in the animals in the placebo group.
- In the human body, dioxin accumulates in fatty tissue and is broken down very slowly. Since breast milk is particularly high in fat, it is considered a good marker for the mother's total dioxin exposure.Women who take chlorella during pregnancy have lower levels of dioxin in their breast milk. It can therefore be assumed that chlorella ensures that less dioxin reaches the unborn child via the umbilical cord.
- Animal experiments also showed that chlorella increases the excretion of dioxin in the urine. Test animals that received an oil containing dioxin and chlorella at the same time excreted more dioxin in the urine than the control animals. This result suggests that chlorella reduces the absorption of dioxin in the intestine and can thus protect against (chronic) dioxin poisoning.
immune system
- Taking 6 g of chlorella daily for one month leads to a significant increase in immunoglobulin A in saliva.
- Increased IgA levels are also found in breast milk if the mother has taken chlorella during pregnancy. Immunoglobulin A in breast milk offers the breastfed child protection against infections.
Pains
- In a study from 2000, the pain of fibromyalgia patients was significantly reduced by taking chlorella. The patients reported an improvement in symptoms of 20-50% after taking chlorella.
Gastrointestinal
- In animal experiments, an increase in lactobacilli was shown when taking Chlorella vulgaris. These regulate the pH value in the intestines by producing lactic acid, thus promoting digestion and also protecting against potential pathogens. Salmonella and pathologically increased E. coli, on the other hand, decrease when taking Chlorella.
- Taking chlorella can reduce oxidative stress in the intestines and strengthen the microflora. This has a positive effect on the intestinal mucosa and its barrier function. This prevents bacteria, bacterial toxins or other harmful substances from entering the bloodstream.
- In a placebo-controlled, double-blind study, Merchant et al. investigated the effect of chlorella on ulcerative colitis. They found that chlorella promotes wound healing and also improves immune function. This significantly improved the symptoms of colitis patients.
- Tamaka et al. found that taking Chlorella vulgaris can counteract the development of stress-related ulcers in the gastric mucosa. This preventive effect is probably due to the positive influence on the gut-brain axis and the protection of the gastric mucosa.
obesity
- In two studies, scientists gave subjects with non-alcoholic fatty liver disease 4 tablets of 300 mg chlorella per day. After taking the tablets for 8 weeks, positive results were seen: the study participants who took chlorella lost more weight than those in the placebo group. In addition, insulin sensitivity improved in the chlorella group, which can reduce the risk of diabetes, a possible secondary disease of obesity.
liver
- In their 2014 study, Aliashrafi et al. administered 300 mg of chlorella per day to patients with fatty liver disease caused by increased calorie intake. After 8 weeks, the liver values alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the blood improved significantly.
- Chlorella can be compared to the study by Noguchi et al.can also be used to prevent non-alcoholic fatty liver disease. In animal experiments, chlorella inhibited the activity of the MCP-1 protein in rats fed a fatty diet. The algae also inhibited the growth of fat cells in the liver.
- Byun et al. showed that a Chlorella vulgaris extract could reduce alcohol-induced liver damage, among other things by reducing γ-glutamyltransferase and glutamic pyruvic transaminase in the blood.
- Responsible for the liver-protective effect is, among other things, a so-called “lutein-protein complex” (LPC), which was extracted from chlorella for the first time by Cai et al. in 2015. In animal models, the LPC showed a positive effect on liver cells.
- Chlorella can be used as a supportive treatment for people with hepatitis C. In a 2013 study, patients with chronic liver inflammation were given Chlorella vulgaris over a period of 3 months. This not only improved their liver values in the blood, but more than 70% of the study participants also reported an improvement in their general well-being (in particular, the fatigue typical of the disease improved in 60% of the participants).
cardiovascular system
- Various studies have shown a positive effect of Chlorella vulgaris on blood pressure. They showed an improvement in both systolic and diastolic blood pressure values.
- Studies have shown that people with high cholesterol and triglyceride levels in their blood can benefit from taking chlorella. The microalgae can significantly reduce the level of fat in the blood. In a 2014 study, scientists were able to reduce the cholesterol levels of their subjects by an average of 1.6%. The level of triglycerides even fell by almost 12%. Chlorella also had a positive effect on the ratio of "bad" LDL cholesterol to "good" HDL cholesterol. While the level of LDL cholesterol decreased, HDL cholesterol increased by 4%.
acid-base balance
- The ideal pH value of the blood, at which metabolic processes can run optimally, is 7.4 and is therefore in the slightly alkaline range. However, due to diet (e.g. lots of meat), stress, etc., the pH value can shift into the acidic range. In order for the body to be able to buffer acidic end products, it needs alkaline minerals such as iron, calcium, magnesium or zinc. Since chlorella contains all of these minerals, it can help regulate the acid-base balance.
skin
- Studies have shown that chlorella has positive effects on dry skin or on skin prone to inflammation (acne, neurodermatitis).
- Participants in a Polish study from 2017 reported not only a reduced susceptibility to infections after taking chlorella, but also a noticeable improvement in hair quality and skin condition.
Sources
- Egner PA et al., "Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer." Proc Natl Acad Sci US A. 2001 Dec 4;98(25):14601-6. (Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer.)
- Breinholt V et al., "Dietary chlorophyllin is a potent inhibitor of aflatoxin B1 hepatocarcinogenesis in rainbow trout." Cancer Res. 1995 Jan 1;55(1):57-62.(Dietary chlorophyllin is a potent inhibitor of aflatoxin B1 hepatocarcinogenesis in
- Kensler TW et al., "Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas." Gastroenterology. 2004 Nov;127(5 Suppl 1):S310-8.
- Harttig U, Bailey GS. "Chemoprotection by natural chlorophylls in vivo: inhibition of dibenzo[a,l]pyrene-DNA adducts in rainbow trout liver." Carcinogenesis. 1998 Jul;19(7):1323-6. (Chemoprotection by natural chlorophyll in vivo: inhibition of dibenzo[a,l]pyrene-DNA adducts in rainbow trout liver.)
- Morita K et al., "Chlorophyll derived from Chlorella inhibits dioxin absorption from the gastrointestinal tract and accelerates dioxin excretion in rats." Environ Health Perspect. 2001 Mar;109(3):289-94. (Chlorophyll derived from Chlorella inhibits dioxin absorption from the gastrointestinal tract and accelerates dioxin excretion in rats.)
- Aozasa O et al., "Fecal excretion of dioxin in mice enhanced by intake of dietary fiber bearing chlorophyllin." Bull Environ Contam Toxicol. 2003 Feb;70(2):359-66. (Enhanced fecal excretion of dioxin in mice by intake of dietary fiber bearing chlorophyllin.)
- Lei AP et al., "Removal of fluoranthene and pyrene by different microalgal species." Bioresour Technol. 2007 Jan;98(2):273-80. Epub 2006 Mar 6. (Removal of fluoranthene and pyrene by different microalgal species.)
- Cho YS, et al., "Chemopreventive effect of chlorophyllin on mutagenicity and cytotoxicity of 6-sulfooxymethylbenzo[a]pyrene." Cancer Lett. 1996 Oct 22;107(2):223-8.
- Madrigal-Bujaidar E et al., "Inhibitory effect of chlorophyllin on the frequency of sister chromatid exchanges produced by benzo[a]pyrene in vivo." Mutat Res. 1997 Jan 15;388(1):79-83. (Inhibitory effect of chlorophyllin on the frequency of sister chromatid exchanges produced by benzo[a]pyrene in vivo.)
- Trevors JT et al., "Cadmium transport, resistance, and toxicity in bacteria, algae, and fungi." Can J Microbiol. 1986 Jun;32(6):447-64.
- Nagafuchi S et al., "Effects of dietary nucleotides on serum antibody and splenic cytokine production in mice." Nutr Res. 1997;17:1163-1174.
- Jyonouchi H et al., "Dietary ribonucleotides increase antigenspecific type 1 T-helper cells in the regional draining lymph nodes in young BALB/cJ mice." Nutrition. 2003 Jan;19(1):41-6.
- Maldonado JM et al., "Reversible inactivation by NADH and ADP on Chlorella fusca nitrate reductase." Biochem Biophys Res Commun. 1973 Mar 5;51(1):27-33. (Reversible inactivation by NADH and ADP of Chlorella fusca nitrate reductase.)
- Congress report on the congress "Cancer and Nutrition" Treatment of tumor diseases, Berlin, 30/31 March 2001
- Yu VY "Scientific rationale and benefits of nucleotide supplementation of infant formula." J Paediatr Child Health. 2002 Dec;38(6):543-9.
- Arnaud A et al., "Exogenous nucleosides alter the intracellular nucleotide pool in hepatic cell cultures. Implications in cell proliferation and function." Clin Nutr. 2003 Aug;22(4):391-9. (Exogenous nucleosides alter the intracellular nucleotide pool in hepatic cell cultures.Effects on cell proliferation and function.)
- Torres MI et al., "Dietary nucleotides have cytoprotective properties in rat liver damaged by thioacetamide." Life Sci. 1998;62(1):13-22.
- Hernndez-Muoz R et al., "Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats." Hepatology. 1990 Aug;12(2):242-8. (Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats.)
- Prez MJ et al., "Dietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats." J Nutr. 2002 Apr;132(4):652-7. (Dietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats.)
- Yu VY "Extrauterine growth restriction in preterm infants: importance of optimizing nutrition in neonatal intensive care units." Croat Med J. 2005 Oct;46(5):737-43. (Extrauterine growth restriction in preterm infants: importance of optimizing nutrition in neonatal intensive care units.)
- Agostoni C et al., "Characteristics of the new milks for infants: fatty acids, nucleotides, selenium." Acta Biomed Ateneo Parmense. 1997;68 Suppl 1:29-34. (Characteristics of the new milks for infants: fatty acids, nucleotides, selenium.)
- Chen H et al., "Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes." Diabetes. 2001 Sep;50(9):2040-6. (Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes.)
- Carr HP et al., "Characterization of the cadmium-binding capacity of Chlorella vulgaris." Bull Environ Contam Toxicol. 1998 Mar;60(3):433-40. (Characterization of the cadmium-binding capacity of Chlorella vulgaris.)
- Nordberg M, Nordberg GF "Toxicological aspects of metallothionein." Cell Mol Biol (Noisy-le-grand). 2000 Mar;46(2):45163. (Toxicological aspects of metallothionein.)
- Perales-Vela HV et al., "Heavy metal detoxification in eukaryotic microalgae." Chemosphere. 2006 Jun;64(1):1-10. Epub 2006 Jan 6. (Heavy metal detoxification in eukaryotic microalgae.)
- Wong SL et al., "Detection of toxic organometallic complexes in wastewaters using algal assays." Arch Environ Contam Toxicol. 1997 May;32(4):358-66.
- Saleh AM et al., "The nutritional quality of drum-dried algae produced in open door mass culture." Z Ernahrungswiss. 1985 Dec;24(4):845-63. (The nutritional quality of drum-dried algae produced in open door mass culture.)
- Barashkov VA, Trubachev IN, Gitel`zon II. "Characteristics of the proteins of unicellular organisms as potential components of ecological life-support systems." Kosm Biol Aviakosm Med. 1979 MayJun;13(3):75-80. (Characteristics of the proteins of unicellular organisms as potential components of ecological life-support systems.)
- Cherng JY, Shih MF. "Improving glycogenesis in Streptozocin (STZ) diabetic mice after administration of green algae Chlorella." Life Sci. 2006 Feb 9;78(11):1181-6. (Improving glycogenesis in Streptozocin (STZ) diabetic mice after administration of green algae Chlorella.)
- Rodrguez-Lpez M, Lpez-Quijada C. "Plasma-glucose and plasma-insulin in normal and alloxanized rats treated with Chlorella." Life Sci II. 1971 Jan 8;10(1):57-60. (Plasma-glucose and plasma-insulin in normal and alloxanized rats treated with Chlorella.)
- Lee H et al., "Hypoglycemic action of chlorella" Taiwan Yi Xue Hui Za Zhi, 1977 Mar;76(3):272-6. (Hypoglycemic action of chlorella.)
- Oomen AG et al., "Lead speciation in artificial human digestive fluid." Arch Environ Contam Toxicol. 2003 Jan;44(1):107-15. (Lead speciation in artificial human digestive fluid.)
- Gunnison D, Alexander M. "Basis for the resistance of several algae to microbial decomposition." Appl Microbiol. 1975 Jun; 29(6):729-38. (Basis for the resistance of several algae to microbial decomposition.)
- Isaacs CE et al., "Inactivation of enveloped viruses in human bodily fluids by purified lipids." Ann NY Acad Sci. 1994 Jun 6;724:457-64. (The inactivation of enveloped viruses in human bodily fluids purified from lipids.) (Study as PDF)
- Thormar H et al., "Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides." Ann NY Acad Sci. 1994 Jun 6;724:465-71. (The inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides.)
- Isaacs CE et al., "Antimicrobial activity of lipids added to human milk, infant formula, and bovine milk." J Nutr Biochem. 1995 Jul;6(7):362-366.
- Enig MG "Lauric oils as antimicrobial agents: theory of effect, scientific rationale, and dietary application as adjunct nutritional support for HIV-infected individuals." in Nutrients and Foods in AIDS, RR Watson, ed., CRC Press, Boca Raton, FL, pp. 81-97.
- Petschow BW et al., "Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids." Antimicrob Agents Chemother. 1996 Feb;40(2):302-6. (The susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids.)
- Isaacs CE, Thormar H. "The role of milk-derived antimicrobial lipids as antiviral and antibacterial agents." Adv Exp Med Biol. 1991;310:159-65.
- Crouch AA et al., "Effect of human milk and infant milk formulae on adherence of Giardia intestinalis." Trans R Soc Trop Med Hyg. 1991 Sep-Oct;85(5):617-9. (The effect of human milk and infant formulae on the adherence of Giardia intestinalis.) (Study as PDF)
- Bartol R et al., "Effect of olive oil on early and late events of colon carcinogenesis in rats: modulation of arachidonic acid metabolism and local prostaglandin E(2) synthesis." Gut. 2000 Feb;46(2):191-9.
- Ruiz-Gutierrez V et al., "Role of dietary oleic acid from two different sources on fatty acid composition of erythrocyte membrane and blood pressure in healthy subjects." J Nutr Biochem. 1997;8:689695. (The role of dietary oleic acids from two different sources on fatty acid composition of erythrocyte membrane and blood pressure in healthy subjects.)
- Carluccio MA et al., "Oleic acid inhibits endothelial activation : A direct vascular antiatherogenic mechanism of a nutritional component in the mediterranean diet." Arterioscler Thromb Vasc Biol. 1999 Feb;19(2):220-8.
- Doctor Chlorella! The algae for life. Compendium on the microalgae Chlorella by Dr.Frank Liebke