Pureway -C - real liposomal vitamin C – QIDOSHA

Pureway -C - real liposomal vitamin C

June 06/26/25, 2025from Patrick Linder

Vitamin C (ascorbic acid) is an essential, water-soluble micronutrient that plays a central role in numerous physiological processes, including immune function, collagen synthesis, and antioxidant defense. Despite its fundamental importance for human health, the therapeutic efficacy of conventional vitamin C is limited by its limited bioavailabilityThe absorption of ascorbic acid occurs via saturable transport mechanisms in the small intestine, which means that at higher doses only a small percentage of the absorbed amount actually reaches the bloodstream.

Liposomal vitamin C formulations have established themselves as an innovative solution to these absorption limitations. By encapsulating vitamin C in lipid bilayers, the natural barriers of gastrointestinal absorption are bypassed and significantly improved bioavailability is achievedThis technological advancement opens up new therapeutic possibilities and makes higher cellular vitamin C concentrations possible without the typical gastrointestinal side effects of high oral doses.

Biochemical principles and mechanisms of action

Liposomal technology

Liposomes are microscopic, hollow vesicles composed of phospholipid bilayers that are structurally similar to cell membranes. This similarity allows liposomes to fuse with cell membranes and transport their contents directly into the cell interior. In the case of liposomal vitamin C, the ascorbic acid is encapsulated within the watery interior of the liposomes, thus protecting it from degradation in the gastrointestinal tract.

Liposomal encapsulation overcomes several absorption barriers: First, it protects vitamin C from oxidation and the acidic environment of the stomach. Second, it enables direct transport into the lymphatic system, thereby bypassing the saturable sodium-dependent vitamin C transporters (SVCT1 and SVCT2) in the small intestine. Third, cellular uptake occurs via endocytosis and passive diffusion, allowing for significantly higher intracellular concentrations.

Pharmacokinetic advantages

Clinical studies have shown that liposomal vitamin C significantly increases and prolongs plasma concentrations of ascorbic acid. A randomized, double-blind crossover study with 27 healthy volunteers documented that 500 mg of liposomal vitamin C resulted in 27% higher maximum plasma concentrations (Cmax) and 21% higher area under the curve (AUC0-24) compared to conventional vitamin C. In addition, significantly higher vitamin C concentrations were also observed in leukocytes (+20% Cmax, +8% AUC), which is of particular relevance for immune function.

Clinical evidence on bioavailability

The superior bioavailability of liposomal vitamin C has been demonstrated by several human clinical studies. In a controlled crossover study, Gopi et al. demonstrated that liposomal vitamin C had 1.77-fold higher bioavailability than non-liposomal vitamin C. Participants received identical doses under fasting conditions, and vitamin C levels were measured over 24 hours.

Another study documented a 30% increase in AUC and a 30% prolongation of elevated blood levels after 24 hours with liposomal vitamin C compared to the non-encapsulated form. This prolonged retention is therapeutically significant because it allows for a more continuous supply of vitamin C to the tissues.

Cellular uptake and tissue distribution

The improved bioavailability of liposomal vitamin C is reflected not only in plasma concentrations but also in uptake into various cell types. In vitro studies with Caco-2 cells demonstrated significantly higher permeability of liposomal vitamin C through the intestinal barrier. This improved absorption at the cellular level explains the clinically observed differences in systemic availability.

Ultrasound examinations have, for the first time, directly visualized the improved intestinal absorption of liposomal formulations. The liposomes behave similarly to ultrasound contrast agents, allowing their passage through the gastrointestinal tract to be tracked.

Therapeutic applications

Immune system and infection defense

Vitamin C plays a central role in immune function by supporting leukocyte function, reducing inflammation, and modulating cytokines. Liposomal vitamin C offers particular advantages in this area, as improved cellular uptake leads to higher concentrations in immune cells.

Clinical studies have shown that increased leukocyte vitamin C levels following liposomal supplementation correlate with an improved immune response against infections. These findings are particularly relevant for immunocompromised patients or individuals at increased risk of infection.

Cancer therapy and oncological applications

The role of high-dose vitamin C in cancer therapy has attracted increasing scientific interest in recent years. Studies have shown that, at sufficiently high concentrations, vitamin C can selectively target cancer cells by promoting the formation of hydroxyl radicals and influencing various tumor-related signaling pathways.

Liposomal vitamin C offers the advantage in oncology applications that therapeutically relevant concentrations can be achieved orally without the gastrointestinal side effects of high intravenous doses. A study with liposomally encapsulated epirubicin and ascorbic acid demonstrated impressive antitumor activity in a breast cancer mouse model.

Preclinical studies suggest that liposomal vitamin C may also enhance the efficacy of chemotherapy and radiotherapy. These synergistic effects are attributed to improved cellular uptake and antioxidant properties.

Wound healing and collagen synthesis

Vitamin C is an essential cofactor for prolyl hydroxylases, which are responsible for collagen synthesis and stabilization. A systematic review of the effects of vitamin C on wound healing showed that supplementation increased the likelihood of faster recovery by 3.94-fold.

Liposomal vitamin C demonstrates particular benefits in this area due to improved tissue distribution and higher local concentrations. Preclinical studies have shown that vitamin C increases the activity of collagen-secreting fibroblasts and stimulates type I collagen production.

Cardiovascular health

The antioxidant properties of vitamin C play an important role in protecting against cardiovascular disease. Liposomal vitamin C can more effectively reduce oxidative stress and lower inflammatory markers due to its improved bioavailability.

Studies have shown that liposomal vitamin C supports cardiac function by reducing oxidative stress and improving vascular function. Extended retention in the bloodstream allows for a more continuous antioxidant effect.

PureWay-C: The superior vitamin C formulation

· Unique composition and technology

O PureWay-C represents a revolutionary advancement in vitamin C supplementation and is fundamentally different from conventional liposomal formulations. This patented form combines ascorbic acid with lipid metabolites from triglycerides and citrus bioflavonoids to ensure superior absorption, distribution, and cellular uptake.

O The lipid metabolites in PureWay-C are derived from safe plant sources and blended with ascorbic acid during the manufacturing process. These fatty acid metabolites act as ascorbic acid carriers, increasing intestinal absorption and tissue distribution and subsequently increasing bioavailability through improved cellular uptake kinetics.

· Clinical superiority over other forms of vitamin C

O Scientific evidence for the superiority of PureWay-C is supported by several human clinical studies. A study conducted at the University of Miami School of Medicine with healthy volunteers showed that PureWay-C resulted in the highest average serum vitamin C levels over a 24-hour period compared to ascorbic acid, calcium ascorbate, and Ester-C.

O The study documented that PureWay-C achieved statistically significantly higher serum levels than calcium ascorbate at all time points (1, 2, 4, and 6 hours after oral supplementation). Ester-C showed a smaller, but statistically significant, increase only at the 1- and 4-hour time points.

O Particularly noteworthy is the superior cellular uptake of PureWay-C. Studies from Adelphi University showed that two hours after treatment, human T lymphocytes treated with PureWay-C contained higher levels of vitamin C than any other treatment group studied. This 233% increase in cellular uptake compared to ascorbic acid explains the superior biological activity.

· Antioxidant and anti-inflammatory properties

O PureWay-C exhibits exceptional antioxidant properties that go beyond those of conventional vitamin C.In DPPH assays, PureWay-C demonstrated nearly 100% free radical reduction at 20 μg/ml and oxygen radical scavenging activity of over 1200 μM Trolox equivalents per gram.

O The IC50 value for PureWay-C was 5.58 μg/ml compared to 8.08 μg/ml for ester ascorbate, representing 10.47% greater antioxidant potency. These superior antioxidant properties correlate with reduced inflammatory markers in clinical studies.

O Clinical studies have shown that PureWay-C has significantly stronger anti-inflammatory effects than other forms of vitamin C. Oral supplementation with PureWay-C resulted in greater reductions in plasma C-reactive protein (CRP) and oxidized LDL levels compared to other vitamin C formulations.

O After 24 hours, CRP levels decreased by 15.6% and oxidized LDL by 8.4%. These anti-inflammatory effects are of particular clinical relevance, as chronic inflammation is associated with numerous diseases.

· Neurological and regenerative properties

O A unique aspect of PureWay-C is its superior ability to support neurological function. Clinical studies conducted by Adelphi University demonstrated that PureWay-C has superior ability to protect against neurodegenerative diseases compared to other forms of vitamin C.

O PureWay-C was more active and effective in vitro than ascorbic acid, calcium ascorbate, and Ester-C in stimulating neurite outgrowth, fibroblast wound healing activities, and protecting the immune system from xenobiotic-induced inflammatory mechanisms. It promoted nerve regeneration 12-fold more effectively, stimulated wound healing 3-fold more effectively, and protected the immune system 2.5-fold better against toxins.

Liposomal PureWay-C: The next evolutionary step

Another innovation is the combination of PureWay-C with liposomal technology. Liposomal PureWay-C utilizes LiposoMax™ technology to ensure uniform liposomal encapsulation and guarantee true liposomal technology.

This combination combines the superior properties of PureWay-C with the benefits of liposomal delivery technology. The result is a formulation with maximized absorption, rapid results, and the highest bioavailability available.

Safety profile and tolerability

Liposomal vitamin C has an excellent safety profile and is generally well tolerated. The most commonly reported side effects are mild and occasionally include gastrointestinal disturbances such as nausea, diarrhea, or stomach cramps, especially at higher doses.

Compared to conventional vitamin C, liposomal vitamin C exhibits significantly better gastrointestinal tolerance. The liposomal encapsulation reduces the direct effects on the gastric mucosa and allows for the intake of higher doses without the typical digestive discomfort.

Certain groups of people should exercise special caution when taking liposomal vitamin C. People with kidney problems have an increased risk of kidney stones with high doses of vitamin C. Individuals with hemochromatosis should seek medical advice due to the increased iron absorption caused by vitamin C.

Pregnant women should follow the recommended dosages and consult a doctor before starting supplementation.

Application recommendations

For optimal absorption, liposomal vitamin C should preferably be taken on an empty stomach. For sensitive individuals, taking it with food may improve tolerability without significantly compromising effectiveness.

Taking it early in the day is recommended to avoid possible sleep disturbances. For higher doses, spreading it throughout the day may improve tolerability.

Conclusion

Liposomal vitamin C represents a significant advance in vitamin C supplementation and offers new therapeutic possibilities through improved bioavailability. Clinical evidence clearly demonstrates the superiority of liposomal formulations over conventional vitamin C in terms of absorption, cellular uptake, and therapeutic efficacy.

PureWay-C stands out as the most advanced vitamin C formulation, achieving 233% greater cellular retention through its unique combination of lipid metabolites and citrus bioflavonoids. Clinical studies clearly demonstrate the superiority of PureWay-C over all other available forms of vitamin C.

The combination of PureWay-C with liposomal technology represents the pinnacle of vitamin C innovation, offering maximum absorption with optimal tolerability. This development opens new perspectives for the therapeutic use of vitamin C in the prevention and treatment of various diseases.

For users who want to optimally benefit from the diverse health benefits of vitamin C, liposomal PureWay-C represents the most scientifically sound and effective option. Ongoing research will open up additional areas of application and further strengthen the position of liposomal vitamin C as an essential therapeutic tool.

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Pureway -C - real liposomal vitamin C

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