Magein-only magnesium-l threonate with Novel food approval

June 06/10/25, 2025from Patrick Linder

Magtein® is the best-studied magnesium supplement for supporting brain performance, memory, sleep, and possibly concentration in ADHD. It is the only magnesium compound (Mg-L-threonate) that can cross the blood-brain barrier and thus act directly in the brain.

The clinical data are based on high-quality human studies (double-blind, randomized). Panoramic doses of 1–2 g/day rated as effective and well tolerated:

🧠 1. Improved cognitive functions in healthy adults

study: Double-blind, placebo-controlled, n = 109 healthy adults (18–65 years)
formulation: Magtein® – Magnesium L-threonate combined with phosphatidylserine and vitamins C & D (all available in our shop)
dosage: 2 g/day
Length of time: 30 days
Result: Significant improvement in all five subtests of a clinical memory test and in the overall memory quotient compared to the placebo group https://aidp.com/2022/12/21/aidp-inc-announces-a-new-magtein-human-clinical-published-study-in-nutrients/

🌙 2. Sleep quality & daytime function

study: Randomized, double-blind, placebo-controlled
Participant: 80 adults (35–55 years) with self-reported sleep problems
dosage: 1 g/day magnesium L-threonate
Length of time: 3 weeks
Result:
- Improved deep & REM sleep phases (measured via Oura Ring)
- Better subjective values (Insomnia Severity Index, daily energy, mood) https://www.nutraceuticalsworld.com/breaking-news/magnesium-l-threonate-improves-sleep-quality-clinical-study/

💤 3. Support for ADHD symptoms (piloted)

Study design: Open pilot study (no control group)
Participant: 15 adults with ADHD
dosage: 2 g/day
Length of time: up to 12 weeks
Result: About 50% showed improved concentration and reduced ADHD symptoms

🧪 4.Dosage & Bioavailability

Effective elemental magnesium dose for cognitive effects: 108–144 mg/day – below the RDA (350–420 mg/day) https://europepmc.org/article/PMC/9786204?utm
Special feature: Magnesium L-threonate increases magnesium levels in the brain and cerebrospinal fluid significantly more than other magnesium compounds https://pmc.ncbi.nlm.nih.gov/articles/PMC9786204/?utm

⚠️ Instructions for use

Very good tolerability at doses <=2 g/day
Effect: usually visible after 3–4 weeks of regular use
Interactions: No known relevant drug interactions